SPINY MICE ACTIVATE UNIQUE TRANSCRIPTIONAL PROGRAMS AFTER SEVERE KIDNEY INJURY REGENERATING ORGAN FUNCTION WITHOUT FIBROSIS

Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

Summary: Fibrosis-driven solid organ failure is an enormous burden on global health.Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation.Whether spiny mice also regenerate internal organ injuries is unknown.Here, we show that despite equivalent acute obstructive or ischemic kidney injur

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Applying Finite-Element and Boundary-Element Methods to Select Rational Design Version of Weld-Fabricated Bogie Frame Brackets of Locomotives and Railway Cars

There is proposed method to select rational design version of weld-fabricated bogie frame brackets of bondi 2 seater sofa locomotives and railway cars.The selection is performed in accord with the outcomes of double-phase computation-based stress analysis in the welded joints.At the first stage general stressed state of a bogie frame as a whole is

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Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol

Solubility is a critical parameter controlling drug absorption after oral administration.For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues.This study has applied a small scale design of experiment (D

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