Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
Summary: Fibrosis-driven solid organ failure is an enormous burden on global health.Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation.Whether spiny mice also regenerate internal organ injuries is unknown.Here, we show that despite equivalent acute obstructive or ischemic kidney injur